Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of α1-antitrypsin into the coatings.

نویسندگان

  • Zheng-Liang Zhi
  • Jashandeep Singh
  • Amazon L F Austin
  • David C D Hope
  • Aileen J King
  • Shanta J Persaud
  • Peter M Jones
چکیده

A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.

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عنوان ژورنال:
  • Chemical communications

دوره 51 53  شماره 

صفحات  -

تاریخ انتشار 2015